Jacobijn Gussekloo Selected Research

Thyroxine (Levothyroxine)

1/2022	Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank.
1/2022	Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: A nested study within a randomized placebo controlled trial.
1/2022	No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials.
11/2021	Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis.
1/2021	Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism: An Ancillary Study of a Randomized Clinical Trial.
1/2021	Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials.
11/2020	An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms.
1/2020	Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial.
1/2020	L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial.
1/2020	The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial.

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Jacobijn Gussekloo Research Topics

Disease

26	Hypothyroidism 01/2022 - 09/2010
23	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2002
15	Cognitive Dysfunction 01/2021 - 06/2002
10	Dementia (Dementias) 01/2021 - 01/2002
10	Heart Failure 01/2021 - 11/2009
8	Anemia 01/2022 - 11/2008
8	Stroke (Strokes) 11/2019 - 06/2002
6	Coronary Disease (Coronary Heart Disease) 01/2020 - 02/2014
5	Hyperthyroidism 11/2021 - 05/2012
5	Chronic Disease (Chronic Diseases) 10/2020 - 09/2004
5	Warts (Wart) 05/2015 - 05/2010
4	Pain (Aches) 01/2022 - 05/2015
4	Inflammation (Inflammations) 04/2015 - 07/2007
4	Urinary Tract Infections (Urinary Tract Infection) 01/2015 - 07/2013
3	Atrial Fibrillation 01/2021 - 06/2014
3	Fatigue 01/2020 - 02/2017
3	Frailty 01/2019 - 09/2004
3	Hearing Loss (Hearing Impairment) 01/2016 - 07/2003
3	Myocardial Infarction 06/2014 - 01/2010
3	Infections 07/2013 - 07/2003
3	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 07/2012 - 11/2008
2	Knee Osteoarthritis 01/2022 - 04/2020
2	Neoplasms (Cancer) 01/2022 - 01/2019
2	Wounds and Injuries (Trauma) 05/2017 - 10/2013
2	Body Weight (Weight, Body) 02/2017 - 01/2017
2	Myalgia 05/2016 - 01/2016
2	Chronic Obstructive Pulmonary Disease (COPD) 11/2015 - 09/2014
2	Diabetes Mellitus 06/2015 - 01/2009
2	Human Influenza (Influenza) 06/2011 - 05/2009
2	Heart Valve Diseases (Valvular Heart Disease) 11/2010 - 04/2010
1	Hip Fractures (Intertrochanteric Fractures) 01/2022
1	Pneumonia (Pneumonitis) 11/2019
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2019
1	Muscular Atrophy (Muscle Atrophy) 01/2019
1	Huntington Disease (Huntington's Disease) 01/2019
1	Nervous System Heredodegenerative Disorders 01/2019
1	Chronic Renal Insufficiency 01/2019
1	Atrophy 01/2019
1	Hypersensitivity (Allergy) 11/2018
1	Hepatic Insufficiency 11/2018
1	Osteoporosis 01/2018
1	Carotid Artery Diseases 01/2018
1	Atherosclerosis 01/2018
1	Hypertension (High Blood Pressure) 01/2017
1	Muscle Weakness 01/2016

Drug/Important Bio-Agent (IBA)

25	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2022 - 12/2004
15	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2022 - 12/2004
12	Thyroid HormonesIBA 01/2022 - 01/2017
8	pro-brain natriuretic peptide (1-76)IBA 01/2016 - 11/2010
6	Antihypertensive Agents (Antihypertensives)IBA 01/2022 - 01/2013
6	Pravastatin (Pravachol)FDA LinkGeneric 01/2022 - 01/2012
6	HomocysteineIBA 02/2017 - 10/2005
5	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2016 - 01/2013
4	Hemoglobins (Hemoglobin)IBA 01/2022 - 03/2013
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021 - 01/2016
4	C-Reactive ProteinIBA 02/2017 - 01/2009
4	Interleukin-6 (Interleukin 6)IBA 02/2017 - 09/2004
4	Biomarkers (Surrogate Marker)IBA 02/2017 - 01/2009
4	Folic Acid (Vitamin M)FDA LinkGeneric 07/2012 - 10/2005
3	HDL CholesterolIBA 01/2009 - 06/2002
3	Interleukin-10 (Interleukin 10)IBA 09/2004 - 04/2002
2	GlucocorticoidsIBA 01/2022 - 04/2020
2	LDL CholesterolIBA 01/2021 - 07/2003
2	CholesterolIBA 01/2021 - 06/2002
2	GoldIBA 11/2015 - 09/2014
2	NitrogenIBA 05/2015 - 10/2010
2	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 05/2015 - 10/2010
2	Glucose (Dextrose)FDA LinkGeneric 04/2015 - 04/2002
2	LipidsIBA 01/2015 - 04/2002
2	Hormones (Hormone)IBA 01/2013 - 08/2012
2	Apolipoproteins E (ApoE)IBA 09/2012 - 01/2002
2	ApolipoproteinsIBA 09/2012 - 01/2002
2	VaccinesIBA 06/2011 - 05/2009
2	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 06/2010 - 11/2008
2	Pharmaceutical PreparationsIBA 01/2010 - 01/2005
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 07/2007 - 09/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2004 - 06/2004
2	CytokinesIBA 09/2004 - 04/2002
2	Lipoproteins (Lipoprotein)IBA 07/2003 - 04/2002
1	antineoplaston A10 (A 10)IBA 01/2022
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2021
1	polyglutamineIBA 01/2019
1	tributyl phosphate (TBP)IBA 01/2019
1	Acetaminophen (Paracetamol)FDA LinkGeneric 11/2018
1	Floxacillin (Flucloxacillin)IBA 11/2018
1	CalciumIBA 01/2018
1	Vitamin D FDA LinkGeneric 01/2018
1	ORALIT (ORS)IBA 01/2017
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 05/2016

Therapy/Procedure

12	Activities of Daily Living (ADL) 01/2022 - 10/2005
11	Therapeutics 01/2022 - 10/2010
7	Long-Term Care 11/2018 - 05/2009
4	Cryotherapy (Therapy, Cold) 05/2015 - 10/2010
2	Polypharmacy 10/2020 - 01/2020
2	Length of Stay 05/2017 - 05/2014
1	Intra-Articular Injections 04/2020
1	Aftercare (After-Treatment) 01/2020
1	Duration of Therapy 01/2020
1	Bathroom Equipment 01/2016
1	Secondary Prevention 01/2016